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Is Gabapentin Addictive?

Key takeaways
  • Yes, gabapentin, sold as Neurontin or Gralise, can be addictive, especially with misuse despite valid medical uses.
  • The risk of gabapentin addiction is considered low compared to other commonly abused drugs like opioids.
  • Factors increasing addiction risk include a history of substance abuse or using higher doses than medically prescribed.
  • Stopping gabapentin suddenly can cause uncomfortable withdrawal symptoms like anxiety, insomnia, and potentially seizures.

Gabapentin is generally seen as safe and effective for these purposes. However, recent concerns have been raised about whether the drug could lead to gabapentin addiction.

Understanding a Gabapentin Addiction

Gabapentin, sold under brand names like Neurontin and Gralise, is a medication for epilepsy, neuropathic pain, and restless leg syndrome. It is also sometimes prescribed off-label for conditions such as anxiety, migraines, and insomnia.

Is Gabapentin Addictive?

Yes, gabapentin can be addictive. While many people use it for valid medical reasons, some may misuse the drug and develop an addiction.

Frequent use of gabapentin can lead to physical dependence, which is a normal bodily response when a drug is taken regularly.

If a physical dependence on gabapentin is developed, you will experience withdrawal symptoms whenever you lower the dose or stop using it.

While gabapentin is not considered a controlled substance by the Drug Enforcement Administration (DEA), there have been reports of people abusing the drug for recreational reasons.

Some people who abuse gabapentin report feeling a sense of euphoria or a \”high\” similar to the one produced by drugs like marijuana or opioids.

However, the risk of gabapentin addiction is fairly low compared to other commonly abused drugs.

Unlike opioids, for example, gabapentin does not cause a physical dependence that results in withdrawal symptoms when the medication is stopped. In addition, studies have shown that the drug has a low potential for abuse compared to other substances.

That said, certain factors may increase the risk of developing a gabapentin addiction. One risk is a history of substance abuse or addiction, as individuals with a past struggle may be more likely to abuse the drug and develop dependence.

Another risk factor is taking higher doses of gabapentin than prescribed or using it longer than recommended. This can increase the chance of side effects such as dizziness, drowsiness, and poor coordination. These effects can be dangerous, especially when combined with other substances like alcohol.

It is also important to note that gabapentin can interact with other drugs, including opioids and benzodiazepines. Combining these drugs increases the risk of side effects and may lead to an overdose or even death.

How Does Gabapentin Work?

Gabapentin works by changing the activity of certain neurotransmitters in the brain, such as gamma-aminobutyric acid (GABA).

GABA is a natural brain chemical that helps control brain activity. It is involved in reducing anxiety, promoting relaxation, and causing sleep.

By increasing the amount of GABA in the brain, gabapentin can help to reduce seizures and relieve neuropathic pain.

However, the exact way gabapentin produces these effects is not fully understood and is still under study.

Gabapentin Uses in Addiction Treatment

Some researchers believe gabapentin may also affect the release of other brain chemicals like glutamate and norepinephrine, which could help explain its benefits.

Gabapentin has also been studied for its potential use in addiction treatment.

Some research suggests the drug may be effective in reducing cravings and withdrawal symptoms related to alcohol and opioid dependence.

One study found that gabapentin was as effective as benzodiazepines for treating alcohol withdrawal but with fewer side effects. Another study found that gabapentin reduced symptoms of opioid withdrawal and made it more likely for patients to complete detox treatment.

However, more research is needed to fully understand gabapentin’s role in addiction treatment. It is important to note that this drug should only be used under a doctor’s care as part of a full treatment plan that includes counseling and therapy.

Gabapentin Side Effects

Gabapentin is generally considered safe, but like all medications, it can cause side effects. Some of the most common side effects include dizziness, drowsiness, and fatigue. Other side effects may include:

  • Nausea and vomiting
  • Headache
  • Dry mouth
  • Diarrhea or constipation
  • Blurred vision
  • Difficulty speaking or slurred speech

More serious side effects are rare but can happen. These may include mood changes like depression or suicidal thoughts, allergic reactions like hives or trouble breathing, and swelling of the face, lips, tongue, or throat.

If you experience any unusual symptoms while taking gabapentin, it is important to contact your doctor right away. They can help determine if the symptoms are related to the medication and advise on the next steps.

Symptoms of Gabapentin Withdrawal

Symptoms of gabapentin withdrawal can be uncomfortable and may include insomnia, anxiety, sweating, nausea, vomiting, restlessness, and seizures.

The severity and length of withdrawal symptoms can vary depending on the person and the dose they were taking. It is important to slowly lower gabapentin use under a doctor’s supervision to reduce the risk of withdrawal.

If you have any unusual symptoms while tapering off gabapentin, contact your doctor right away. They can determine if the symptoms are related to the drug and advise on the next steps.

Symptoms of Gabapentin Overdose

Symptoms of gabapentin overdose can be serious and require immediate medical attention. Symptoms of a gabapentin overdose can be serious and need immediate medical help. Common signs of an overdose include difficulty breathing, extreme drowsiness, blurred vision, slurred speech, and loss of consciousness. In severe cases, it can lead to a coma or death.

You must seek emergency medical care if you think that you or someone else has taken too much gabapentin.

In addition, it is important to track your medication and take it only as your doctor prescribed to lower the risk of an overdose.

Why Is Gabapentin Addictive?

Gabapentin can be addictive for several reasons. For one, the drug can cause feelings of relaxation and euphoria in some users, which can create a psychological dependence.

Additionally, gabapentin is often used to manage chronic pain, anxiety, and other conditions that can last for a long time.

This means that patients may take the drug for long periods, sometimes even years, which increases the chance of developing a physical dependence on it.

Finally, some people may abuse gabapentin as a way to increase the effects of other drugs, such as opioids or benzodiazepines.

When taken with these substances, gabapentin can increase their strength and produce more intense effects.

FAQs

Can I become addicted to gabapentin if I use it as prescribed?

While the risk of gabapentin addiction is fairly low, it is still possible to become addicted even when using the drug as prescribed. It’s important to follow your doctor’s instructions carefully and tell them if you experience any unusual symptoms or side effects.

How do I know if I am becoming addicted to gabapentin?

Signs of a gabapentin addiction may include taking higher doses than prescribed, craving the drug, or continuing to use it despite negative problems like poor performance at work or relationship issues. It’s important to seek help from a doctor or addiction specialist if you think you might be struggling.

Can I stop taking gabapentin on my own?

If you have been taking gabapentin for a long time, it is important to slowly lower the dose under a doctor’s care to reduce the risk of withdrawal symptoms. Trying to stop taking gabapentin suddenly can lead to uncomfortable and potentially dangerous symptoms.

What should I do if someone I know is struggling with gabapentin addiction?

If you suspect that someone you know is struggling with a gabapentin addiction, it is important to encourage them to get help from a doctor or addiction specialist. You can also provide emotional support and offer resources like helplines or support groups.

Are there any alternative medications that can be used instead of gabapentin?

Depending on the condition being treated, there may be other medications or therapies that can be used instead of or with gabapentin. It is important to discuss all treatment options with your doctor and work together to create a full treatment plan that meets your personal needs.

Summary

In summary, gabapentin is not generally considered highly addictive, but there is some potential for misuse and dependence. Individuals with a history of substance use or those taking higher-than-prescribed doses may be at increased risk and should be monitored closely for signs of abuse.

It is important to consult a healthcare provider before starting or discontinuing gabapentin, and to always follow the prescribed dosage and instructions. Proper medical guidance helps reduce the risk of dependence and ensures the medication is used safely and effectively.

Sources

  1. https://americanaddictioncenters.org/addiction-medications/gabapentin
  2. https://www.addictioncenter.com/drugs/gabapentin/
  3. https://www.drugs.com/medical-answers/gabapentin-addictive-3573085/
  4. https://www.statnews.com/2017/07/06/gabapentin-becomes-target-of-opioid-abuse/

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Medical Reviewer

Dr. Singh

Dr. Deepraj Singh is a board-certified psychiatrist. She graduated from Albany Medical College and completed her residency at Drexel University. Due to her passion for learning as well as teaching, she joined the Drexel University faculty to teach resident physicians and medical students. She started out her career in emergency psychiatry, but has expanded into working in outpatient, day program, inpatient and targeted case management programs. She is also certified in ECT and TMS. She performed ECT for persons with severe depression, anxiety, and bipolar disorders. She has always been interested in ways to improve care for her patients. This has led her to pursuing leadership roles such as medical directorships at various outpatient programs and inpatient facilities. These opportunities have allowed her to make changes at an organization level as well as community level. She strives to provide a comfortable atmosphere and a thorough evaluation. She believes in the holistic approach to care, aspires to integrate the biopsychosocial aspects as well physical health, and nutrition into her evaluation and treatment of her patients.

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